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Research to investigate
link between hormone resistance and prostate cancer
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2002
- Prostate cancer is one of the leading causes of death among
men in the United States. Although active research on prostate
cancer is ongoing, the molecular basis of prostate cancer has
not been established well enough to develop curative therapies.
- The treatment of choice for many prostate cancer patients is
hormonal therapy to remove serum testosterone. While this approach
is initially effective, the disease often develops "hormone
resistance" and continues to progress, ending in death. By
understanding the molecular mechanisms which contribute to the
development of hormone resistance, researchers hope to develop
more targeted therapies.
- Yoshiki Iwamoto, MD, Ph D (Urology) has received a grant
from the Gustavus and Louise Pfeiffer research Foundation to continue
his research of this molecular process, using novel DNA chip technology.
- Dr. Iwamoto's team - which includes William See, MD (Urology);
Howard Jacob, PhD (Human and Molecular Genetics); and Michiko
Onuma, PhD (Urology) - will use the Pfeiffer award to attempt
to identify genes involved in testosterone-independent growth
of prostate cancer cells.
- For more information about this research, contact Dr. Iwamoto
at 414-456-4678.
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