The Transgenic Core facility (TC) supports research projects involving
the generation of mutant mouse strains through gene targeting experiments
in murine embryonic stem cells, generation of mutant mouse strains
from gene targeted embryonic stem cells, generation of transgenic
mouse strains via injection of fertilized eggs with DNA constructs,
and a variety of other embryo manipulation techniques, such as
cryopreservation, embryo-rederivation by caesarian section and
embryo transfer, and tetraploid embryo aggregation.
Current projects include studies of the developmental function
of
Coagulation proteases, identification of genetic risk factors for
thrombosis, and generation and analysis of mouse models of human
disease (sepsis, diabetes, thrombosis).
The Transgenic Core facility (TC) supports research projects involving
the generation of mutant mouse strains through gene targeting experiments
in murine embryonic stem cells, generation of mutant mouse strains
from gene targeted embryonic stem cells, generation of transgenic
mouse strains via injection of fertilized eggs with DNA constructs,
and a variety of other embryo manipulation techniques, such as
cryopreservation, embryo-rederivation by caesarian section and
embryo transfer, and tetraploid embryo aggregation. 
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