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 Michalkiewicz Lab

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Michalkiewicz Lab Projects

Gene Function In The Whole Animal
 
Members & Collaborators

E. Bytchkova, M. Heilig, H. Jacob, K. Knestaut, A. Lernmark, T. Michalkiewicz, V. Petruhkina, R. Quirion, A. Vezzani

• Research Interests
• Neural control of blood pressure and cardiac function.
  Peptidergic neurotransmitters of the sympathetic nervous system.
  Physiological role of neuropeptide Y.
  Genetic polymorphism of neuropeptides.
  Genetics of hypertension, heart failure, and obesity.

• Discovering the functions of a novel gene: 'Gene-to-phenotype' approach
• Addition of function mutation: the phenotypes of NPY transgenic rats
  

• Discovering novel cardiovascular disease genes: 'Phenotype-to-gene' approach
• Transgenic rescue and functional cloning (BAC transgenic rats)

• We are focused on a number of rat models in which a disease has been linked to a critical genomic region. These include:
  -Fisher/Lyp rat and lymphopenia gene,
  -FHH rat and end stage renal disease gene,
  -SS rat and gene responsible for salt sensitive hypertension,
  -GK rat and diabetes type II gene,
  -Stroke prone rats and genes responsible for stroke.
• Corresponding to the mutated allele, large DNA clones (PACs, BACs, YACs) containing normal sequences are used as transgenes.
  Alleviation of the disease symptoms after genomic incorporation of the transgene will provide critical evidence for the identification of the disease gene.
  

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