Broeckel, Ulrich M.D.
Assistant Professor
Specialization: Human Clinical Genetics
Tel: (414) 456-4409 Dr. Broeckel's CV
Email:
Human Genetics Resource Program Director: Ulrich Broeckel, MD
Many diseases have a genetic component. The Broeckel Lab works to identify candidate genes and Single Nucleotide Polymorphisms (SNPs) that are involved in various diseases. In addition, further analysis is performed to isolate specific genes that may be involved in predisposing a person to the development of a disease.
The tools used for genetic analysis include: genotyping/SNP typing,
sequencing, fluorescent genotyping of microsatellites, and gene
mapping using 100K SNP chips from Affymetrix. The focus is analysis
of DNA samples extracted from human white blood cells or tissue
samples. The genetic analysis examines results for samples from
individuals having a particular disease and comparing them to those
of individuals not having the disease. Many times, analysis will
incorporate samples from as many members of a family as are willing
to participate.
The Broeckel Lab is studying numerous diseases, some which include:
breast cancer, pediatric inflammatory bowel disease, cardiovascular
diseases,
and end-stage renal disease. Several ongoing studies fall under
the cardiovascular disease umbrella and these consist of hypertension,
C-reactive Protein involvement in myocardial infarction, coronary
artery disease, and left ventricular hypertrophy. Many of these
studies lend themselves to collaborate with other basic and clinical
scientists. Future collaborations are also planned to expand to
other pediatric diseases.
The Broeckel Lab works closely with the Human
Genetics Resource Program (HGRP) recruitment staff that supplies the DNA and tissue
samples to be
analyzed and also the bioinformatics personnel within the HMGC.
Ongoing studies are:
HyperGen: Genetic Epidemiology of Left Ventricular Hypertrophy
Genetics of CRP in Myocardial Function
SCOR: Molecular Genetics of Hypertension
Genetic Predisposition to End-Stage Renal Disease
Epidemiology
Genetics of Female Breast Cancer
Genotype/phenotype correlation in new onset pediatric Crohn’s disease
The Broeckel Lab is studying numerous diseases, some which include:
breast cancer, pediatric inflammatory bowel disease, cardiovascular
diseases,
and end-stage renal disease. Several ongoing studies fall under
the cardiovascular disease umbrella and these consist of hypertension,
C-reactive Protein involvement in myocardial infarction, coronary
artery disease, and left ventricular hypertrophy. Many of these
studies lend themselves to collaborate with other basic and clinical
scientists. Future collaborations are also planned to expand to
other pediatric diseases.
Click
